Kineta Initiates First-in-Human Clinical Trial of LHF-535 a Novel Therapy for Lassa Fever

Kineta Initiates First-in-Human Clinical Trial of LHF-535 a Novel Therapy for Lassa Fever

Phase 1 study to assess the safety, tolerability and pharmacokinetic profile of LHF-535 in healthy volunteers

No therapy or vaccine currently approved for use in Lassa fever

Seattle, WA, September 5, 2018 – Kineta, Inc., an emerging biotechnology company focused on the development of novel immunotherapies and antiviral drugs announced today the initiation of a first-in-human, Phase 1a clinical trial of its antiviral drug LHF-535 to treat Lassa hemorrhagic fever. Lassa fever is an acute, viral illness endemic in West Africa that causes an estimated 100,000-300,000 infections and up to 5,000 deaths annually.1

The main objectives of the Phase 1a clinical study are to assess the safety, tolerability and pharmacokinetic profile of LHF-535 in healthy subjects. This single-ascending dose (SAD) study will be conducted in up to 56 healthy subjects randomized into 5-7 cohorts of 8 subjects each.  Results of the SAD clinical study are expected in the first quarter of 2019.  A Phase 1b multiple-ascending dose (MAD) clinical study is planned to commence in 2019 following the completion of the Phase 1a study.

“We are very excited to initiate the first-in-human study of our lead drug candidate LHF-535, a first-in-class antiviral for Lassa fever”, said Kineta CEO, Shawn Iadonato.  “The recent outbreaks of Ebola and Zika viruses remind us of the critical need to develop new therapies for neglected tropical diseases and biodefense threats like Lassa fever. We were also pleased that the FDA recently added Lassa fever to the Tropical Disease Priority Review Voucher Program, further validating the need for an effective therapy”.2

LHF-535 is an oral antiviral with potent activity against Lassa fever and other arenaviruses, as demonstrated in preclinical studies. Its mechanism of action involves inhibiting virus entry into target host cells and suppressing viral replication. LHF-535 was well-tolerated in preclinical studies and reduced virus titers and enhanced survival in animal models of Lassa fever.

Kineta received a Wellcome Trust Translation Fund Award of up to $7.2 M in 2016 to advance the development of LHF-535 to treat Lassa fever though Phase 1 clinical studies.

 

References:

  1. US CDC. Lassa fever: fact sheet (09/04/2018)

https://www.cdc.gov/vhf/lassa/pdf/factsheet.pdf

  1. FDA addition of Lassa fever to Tropical Disease Priority Review Voucher Program https://www.fda.gov/aboutfda/centersoffices/officeofmedicalproductsandtobacco/cder/ucm534162.htm

                                                                                                                                                                                                     

Kineta, Inc. is an emerging biotechnology company that is focused on the translational development of first-in-class therapies from discovery to proof of concept.  Kineta is developing a focused pipeline of novel drug candidates that address critical unmet patient needs in neuroscience, immuno-oncology and biodefense. We actively collaborate with a broad array of private, government, biodefense and industry partners to advance our innovative research. Development of LHF-535 for Lassa fever is through Kineta Inc.’s subsidiary Kineta Viral Hemorrhagic Fever, LLC. For more information on Kineta, Inc. visit our website, www.kinetabio.com.

Wellcome exists to improve health for everyone by helping great ideas to thrive. We’re a global charitable foundation, both politically and financially independent. We support scientists and researchers, take on big problems, fuel imaginations and spark debate.

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NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

 

Contact Jacques Bouchy

jbouchy@kineta.us

(206) 378-0400

 

 

Kineta to Collaborate on the Development of a Novel Non-Opioid Pain Therapy with Genentech

Kineta to Collaborate on the Development of a Novel Non-Opioid Pain Therapy with Genentech

Collaboration to develop a first-in-class α9/α10 nicotinic acetylcholine receptor antagonist for the treatment of chronic pain

Kineta to receive undisclosed upfront payment and up to $359 million in additional development and commercial milestones.

SEATTLE, WA, April 16, 2018 – Kineta Chronic Pain, LLC, a subsidiary of Kineta, Inc., today announced that it has entered into an exclusive option and license agreement with Genentech, a member of the Roche Group, to develop Kineta’s α9/α10 nicotinic acetylcholine receptor (nAChR) antagonists for the treatment of chronic pain.

The α9/α10 nAChR is a novel target for the treatment of chronic neuropathic pain. Preclinical data showed investigational compounds that specifically target the receptor reduced pain behaviors in animal models and demonstrated disease-modifying effects including reduced inflammation and nerve protection at the site of the injury.  This novel target is not believed to be expressed in the central nervous system and may lead to a safer therapy that is non-addictive and non-tolerizing.

“We are very excited to collaborate with Genentech as they are one of the world’s leading biotech companies and an ideal strategic partner for Kineta”, said Kineta CEO, Shawn Iadonato. “There is a tremendous unmet patient need to develop more effective, safer and non-addictive therapies for the many people who suffer from chronic pain. By collaborating with Genentech, we expect to accelerate the development of our promising novel non-opioid therapy for patients.”

“We are excited to join forces with Kineta to develop potentially life-changing medicines for people with chronic pain conditions,” James Sabry, M.D., Ph.D., Senior Vice President and Global Head of Genentech Partnering.

Under the terms of the agreement, Kineta will receive an undisclosed upfront payment and is eligible to receive development and commercialization milestone payments up to $359 million based on achievement of certain predetermined milestones.  Additionally, Kineta is eligible to receive high single to low double-digit royalties on sales of certain products resulting from the collaboration.  Genentech has an option to license assets developed during the collaboration. If Genentech exercises its option under the agreement, Genentech will be responsible for further development and commercialization.

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Kineta, Inc. is an emerging biotech company that is focused on the translational development of first-in-class therapies from discovery to proof of concept.  Kineta is developing a focused pipeline of novel drug candidates that address critical unmet patient needs in neuroscience, immuno-oncology, rare diseases and biodefense. We actively collaborate with a broad array of private, government, biodefense and industry partners to advance our innovative research. Development of the α9/α10 nAChR antagonists for chronic pain is thru Kineta Inc.’s subsidiary Kineta Chronic Pain LLC. For more information on Kineta, Inc. visit our website, www.kinetabio.com

NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Contact:
Jacques Bouchy
jbouchy@kineta.us
(206) 378-0400

Kineta to Collaborate on the Development of a Novel Non-Opioid Pain Therapy with Genentech

Kineta to Collaborate on the Development of a Novel Non-Opioid Pain Therapy with Genentech

Collaboration to develop a first-in-class α9/α10 nicotinic acetylcholine receptor antagonist for the treatment of chronic pain

Kineta to receive undisclosed upfront payment and up to $359 million in additional development and commercial milestones.

SEATTLE, WA, April 16, 2018 – Kineta Chronic Pain, LLC, a subsidiary of Kineta, Inc., today announced that it has entered into an exclusive option and license agreement with Genentech, a member of the Roche Group, to develop Kineta’s α9/α10 nicotinic acetylcholine receptor (nAChR) antagonists for the treatment of chronic pain.

The α9/α10 nAChR is a novel target for the treatment of chronic neuropathic pain. Preclinical data showed investigational compounds that specifically target the receptor reduced pain behaviors in animal models and demonstrated disease-modifying effects including reduced inflammation and nerve protection at the site of the injury.  This novel target is not believed to be expressed in the central nervous system and may lead to a safer therapy that is non-addictive and non-tolerizing.

“We are very excited to collaborate with Genentech as they are one of the world’s leading biotech companies and an ideal strategic partner for Kineta”, said Kineta CEO, Shawn Iodonato. “There is a tremendous unmet patient need to develop more effective, safer and non-addictive therapies for the many people who suffer from chronic pain. By collaborating with Genentech, we expect to accelerate the development of our promising novel non-opoid therapy for patients.”

“We are excited to join forces with Kineta to develop potentially life-changing medicines for people with chronic pain conditions,” James Sabry, M.D., Ph.D., Senior Vice President and Global Head of Genentech Partnering.

Under the terms of the agreement, Kineta will receive an undisclosed upfront payment and is eligible to receive development and commercialization milestone payments up to $359 million based on achievement of certain predetermined milestones.  Additionally, Kineta is eligible to receive high single to low double-digit royalties on sales of certain products resulting from the collaboration.  Genentech has an option to license assets developed during the collaboration. If Genentech exercises its option under the agreement, Genentech will be responsible for further development and commercialization.

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Kineta, Inc. is an emerging biotech company that is focused on the translational development of first-in-class therapies from discovery to proof of concept.  Kineta is developing a focused pipeline of novel drug candidates that address critical unmet patient needs in neuroscience, immuno-oncology, rare diseases and biodefense. We actively collaborate with a broad array of private, government, biodefense and industry partners to advance our innovative research. Development of the α9/α10 nAChR antagonists for chronic pain is thru Kineta Inc.’s subsidiary Kineta Chronic Pain LLC. For more information on Kineta, Inc. visit our website, www.kinetabio.com

NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Contact:
Jacques Bouchy
jbouchy@kineta.us
(206) 378-0400

Kineta Immuno-oncology Unveils New Data Demonstrating Tumor Immunity in Multiple Tumor Models

Kineta Immuno-oncology Unveils New Data Demonstrating Tumor Immunity in Multiple Tumor Models

Small molecule RIG-I agonist induces innate immune responses, immunogenic tumor cell death and in vivo protective immune responses in a colon carcinoma model

Tumor regression also demonstrated in B16F10 melanoma model

SEATTLE, WA, April 5, 2018 – Kineta Immuno-oncology, LLC, a biotechnology company focused on developing disruptive technologies to turn cold tumors hot, recently presented new data on their RIG-I Immuno-oncology program at the Keystone Symposia on Molecular and Cellular Biology: Cancer Immunotherapy Combinations.

Dr. Peter Probst, Kineta Immuno-oncology Vice President and Head of Immunology, presented new data on the RIG-I agonist lead chemical series which activates RIG-I-dependent signaling to stimulate chemokine/cytokine production by human PBMCs, and induces direct activation of dendritic cells. The small molecule RIG-I agonists demonstrate significant reduction in tumor growth in two mouse tumor models; CT26 colon carcinoma and B16F10 melanoma.

Additionally, a newly identified RIG-I lead candidate with potent innate immune activation and immunogenic cell death (ICD) activities showing orthogonal confirmation around the lead series was presented. In tumor cells specifically, lead candidates induce the intrinsic apoptosis pathway and trigger ICD in a RIG-I dependent manner. Additionally, in vivo experiments demonstrate tumor immunity as a single dose of compound inhibits tumor growth, enhances survival and causes complete regression of tumor growth in approximately 30% of mice. Mice showing complete tumor regression were resistant to re-challenge for up to 6 months after primary tumor implantation. Animals that were responsive to drug treatment also demonstrated an increase in tumor antigen specific T cells compared to tumor bearing animals.

These data demonstrate that Kineta’s small molecule RIG-I agonists activate the innate immune response, induce ICD in tumor cells in vivo and elicit an anti-tumor memory T cell response controlling tumor growth”, said Dr. Kristin Bedard, Kineta Immuno-oncology Chief Scientific Officer. “Demonstrating significant tumor regression in multiple tumor models and selecting additional drug candidates from the lead chemical series are significant advancements for the program”.


Kineta, Inc. is an emerging biotech company that fills a void in the biopharmaceutical industry by efficiently advancing first in class immuno-therapies from discovery to proof of concept.  Kineta is developing a focused pipeline of novel therapies that address critical unmet patient needs in oncology, chronic pain and biodefense. We actively collaborate with a broad array of private, government, biodefense and industry partners to advance our innovative research. For more information on Kineta, Inc. visit our website, www.kinetabio.com

NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Kineta Immuno-oncology to Present at Keystone Symposia on Molecular and Cellular Biology: Cancer Immunotherapy Combinations Conference

Kineta Immuno-oncology to Present at Keystone Symposia on Molecular and Cellular Biology: Cancer Immunotherapy Combinations Conference

New data on Kineta’s small molecule RIG-I agonists in tumor models to be unveiled

SEATTLE, WA, March 22, 2018 – Kineta Immuno-oncology, LLC, a biotechnology company focused on developing disruptive technologies to turn cold tumors hot, today announced that they have been invited to present at the Keystone Symposia on Molecular and Cellular Biology: Cancer Immunotherapy Combinations. Dr. Peter Probst, Kineta Immuno-oncology Head of Immunology, will present a poster on Kineta’s RIG-I Immuno-oncology program. The conference takes place on March 23-27 at the Fairmont, The Queen Elizabeth Hotel in Montreal, Canada.

Dr. Probst will present new data on Kineta Immuno-oncology’s RIG-I agonists demonstrating significant reduction in tumor growth in two mouse tumor models; CT26 colon carcinoma and B16F10 melanoma. Additionally, a newly identified RIG-I lead candidate with potent innate immune activation and immunogenic cell death activities showing orthogonal confirmation around the lead series will be shown.

Dr. Probst will be presenting scientific poster #3016 entitled “Small molecule RIG-I agonists induce innate immune responses, immogenic tumor cell death and in vivo protective immune responses in a colon carcinoma model” on March 26th between 7:30-10pm.


Kineta, Inc. is an emerging biotech company that fills a void in the biopharmaceutical industry by efficiently advancing first in class immuno-therapies from discovery to proof of concept.  Kineta is developing a focused pipeline of novel therapies that address critical unmet patient needs in oncology, chronic pain and biodefense. We actively collaborate with a broad array of private, government, biodefense and industry partners to advance our innovative research. For more information on Kineta, Inc. visit our website, www.kinetabio.com

NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Kineta Immuno-oncology Announces Presentation on Novel RIG-I Agonists at Immuno-Oncology Frontiers World Conference

Kineta Immuno-oncology Announces Presentation on Novel RIG-I Agonists at Immuno-Oncology Frontiers World Conference

SEATTLE, WA, January 22, 2018 – Kineta Immuno-oncology, LLC, a biotechnology company focused on developing disruptive technologies to turn cold tumors hot, today announced that they have been invited to present at the Immuno-Oncology Frontiers World Conference sponsored by Phacilitate. Dr. Kristin Bedard, Kineta Immuno-oncology Chief Scientific Officer, will present at 2:50PM EST on January 24, 2018. The conference takes place on January 22-25 at the Hyatt Regency Hotel in Miami, FL.

Dr. Bedard will present on the proof of concept compound, KIN131A, which activates RIG-I-dependent signaling to stimulate chemokine/cytokine production by human PBMCs, and induces direct activation of dendritic cells. In colon carcinoma cells, KIN131A treatment induces the intrinsic apoptosis pathway and triggers immunogenic cell death (ICD) in a RIG-I dependent manner. Additionally, in vivo experiments demonstrated tumor immunity as KIN131A inhibits tumor growth, enhances survival and causes complete regression of tumor growth in approximately 30% of mice. Mice showing complete tumor regression were resistant to re-challenge up to 6 months after primary tumor implantation. Animals that were responsive to KIN131A treatment also demonstrated an increase in tumor antigen specific T cells compared to tumor bearing animals.

“These data demonstrate that the RIG-I agonists activate the innate immune response, induce ICD in tumor cells in vivo and elicit an anti-tumor memory T cell response controlling tumor growth”, said Dr. Bedard. “The induction of ICD by small molecule RIG-I agonists may provide a unique immunotherapeutic opportunity to induce or boost the antitumor immune response in patients and enhance the efficacy of checkpoint inhibitor-mediated immunotherapy.”


Kineta, Inc. is an emerging biotech company that fills a void in the biopharmaceutical industry by efficiently advancing first in class immuno-therapies from discovery to proof of concept.  Kineta is developing a focused pipeline of novel therapies that address critical unmet patient needs in oncology, chronic pain and biodefense. We actively collaborate with a broad array of private, government, biodefense and industry partners to advance our innovative research. For more information on Kineta, Inc. visit our website, www.kinetabio.com

NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Kineta to Present at Symposium on Pandemic Preparedness

Kineta to Present at Symposium on Pandemic Preparedness

LHF-535 Lassa fever antiviral and vaccine adjuvant program to be highlighted

Seattle, WA, June 12, 2017 – Kineta, Inc., a biotechnology company focused on the development of novel immuno-therapies, today announced Kineta Vice President of R&D and Head of Virology Kristin Bedard has been invited to present at the Pandemic Preparedness for the Northwest and Beyond meeting sponsored by Life Science Washington.  This Symposium will be held on June 14, 2017 from 8:30-10:30 AM PST at the Agora Conference Center in Seattle, WA.

Dr. Bedard will be joined by other leaders in infectious disease research and the global health community in discussing new approaches to developing drugs and vaccines that will address future pandemic threats. She will present an overview of Kineta’s portfolio and highlight LHF-535, Kineta’s first in class antiviral for Lassa Hemorrhagic Fever as well as the company’s vaccine adjuvant program.

This symposium will discuss threat prediction models, new medical and pharmaceutical research, the role of animals in disease outbreaks along with the roles of local measures, citizens, and businesses in helping mitigate outbreaks.

Click here to learn more about this event.


Kineta, Inc. is an emerging biotech company that fills a void in the biopharmaceutical industry by efficiently advancing first in class immuno-therapies from discovery to proof of concept.  Kineta is developing a focused pipeline of novel therapies that address critical unmet patient needs in oncology, chronic pain and biodefense. We actively collaborate with a broad array of private, government, biodefense and industry partners to advance our innovative research. For more information on Kineta, Inc. visit our website, www.kinetabio.com

NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Kineta to Present at Symposium on Next-Generation Therapeutics for the Treatment of Pain

Kineta to Present at Symposium on Next-Generation Therapeutics for the Treatment of Pain

Seattle, WA, April 25, 2017 – Kineta, Inc., a biotechnology company focused on the development of novel immuno-therapies, today announced Kineta CEO Shawn Iadonato has been invited to present at the Next-Generation Therapeutics for the Treatment of Pain Symposium sponsored by Life Science Washington. This Symposium will be held on April 27, 2017 from 3:30-6:30 PM PST at the Agora Conference Center in Seattle, WA.

Dr. Iadonato will present preclinical data on the disease modifying effects of KCP-400, a novel non-opioid in development for the treatment of chronic pain. This first in class therapeutic has demonstrated robust analgesic, anti-inflammatory and neuroprotective effects in multiple pain models.

This symposium will discuss several innovative therapeutic approaches based on novel pain targets and mechanisms, as well as review new clinical approaches for development. Click Here to learn more about this event.


Kineta, Inc. is an emerging biotech company that fills a void in the biopharmaceutical industry by efficiently advancing first in class immuno-therapies from discovery to proof of concept. Kineta is developing a focused pipeline of novel therapies that address critical unmet patient needs in oncology, chronic pain and biodefense. We actively collaborate with a broad array of private, government, biodefense and industry partners to advance our innovative research. For more information on Kineta, Inc. visit our website, www.kinetabio.com

NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

KCP-400 Relieves Chronic Pain and Demonstrates Disease Modifying Effects

KCP-400 Relieves Chronic Pain and Demonstrates Disease Modifying Effects

Seattle, WA, January 6, 2017 – Kineta, Inc., a biotechnology company focused on the translational development of novel immune modulating therapies, today announced that KCP-400 (RgIA4), a potent antagonist of the α9α10 nicotinic acetylcholine receptor (nAChR), demonstrates robust chronic pain relief and disease modifying effects in preclinical pain models. The study also establishes the α9α10 nAChR as a new, non-opioid target for the treatment of chronic pain. The findings were reported online in the February 20th issue of the Proceedings of the National Academy of Sciences.

KCP-400 is derived from the venom of the Conus regius, a small cone snail native to the Caribbean Sea that uses a venomous punch to paralyze and kill its prey. “Nature has evolved molecules that are extremely sophisticated and can have unexpected applications,” said Dr. Baldomero Olivera, professor in biology at the University of Utah and co-author of the study. “We were interested in using venoms to understand different pathways in the nervous system.”

Using chemotherapy-induced peripheral neuropathy (CIPN) in rodents, researchers from Kineta and the University of Utah, showed that α9α10 nAChRs play a key role in the progression of CIPN and that KCP-400 is an effective compound to block this target. The observed pain relief continued for 72 hours after the compound was injected, indicating that KCP-400 may provide sustained relief of chronic pain.

“KCP-400’s target, the α9α10 nAChR, represents a mechanistically distinct approach to modify the disease course of chronic pain”, said Dr. Shawn Iadonato, CEO of Kineta and co-author of the study. “KCP-400 blocks pain signaling at the site of nerve injury producing analgesic, anti-inflammatory and neuroprotective effects. Additionally, since KCP-400 is peripherally acting, we do not anticipate that it will have the central nervous system-related side effects associated with opioid therapies.”

Public health officials have called the current opioid epidemic the worst drug crisis in American history, killing more than 90 people every day. “There is a tremendous unmet medical need for new chronic pain therapies that are differentiated from currently available treatment options”, said Dr. Iadonato. “We believe that KCP-400, with its novel characteristics, may have a significant and positive impact for patients and their families.

Kineta is conducting ongoing preclinical safety and efficacy studies of KCP-400 in many forms of chronic pain and plans to advance to Phase 1 human clinical trials in mid-2018.


The study was conducted by Kineta in collaboration with colleagues from University of Utah, University of Florence, Italy, A.T. Still University, University of Mississippi Medical Center and the Veterans Affairs Medical Center, Salt Lake City.

This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs through the FY13 DOD USAMRMC Broad Agency Announcement under Award No. W81XWH-15-2-0057.


Kineta, Inc. is an emerging and sustainable biotech company that fills a void in the biopharmaceutical industry by efficiently advancing therapies from discovery to clinical proof of concept. We actively collaborate with a broad array of private, government and industry partners to advance our innovative research in chronic pain, immuno-oncology and infectious diseases. Kineta has established and is expanding on a diverse pipeline of novel life improving therapies that address critical unmet patient needs. For more information on Kineta, Inc. visit our website, www.Kinetabio.com

KCP-400 is a first in class α9α10 nAChR antagonist with a novel mechanism of action. It is a highly potent synthetic peptide that is derived from the venom of a cone snail. KCP-400 is a non-opioid that has demonstrated robust analgesic, anti-inflammatory and neuroprotective effects across multiple preclinical chronic pain models. It is well tolerated with no observed toxicities in short-term studies in animals.

NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Kineta to Present at Biotech Showcase Investor Conference during JP Morgan Week in San Francisco

Kineta to Present at Biotech Showcase Investor Conference during JP Morgan Week in San Francisco

Advances in Chronic Pain Program to be Highlighted

Seattle, WA, January 6, 2017 – Kineta, Inc., a biotechnology company focused on the translational development of novel immune modulating therapies, today announced the company has been invited to present at the 9th Annual Biotech Showcase Investor Conference. Kineta CEO Dr. Shawn Iadonato will provide an overview of the company and KCP-400, a novel non-opioid in preclinical development for the treatment of chronic pain.

Dr. Iadonato will outline the robust analgesic, anti-inflammatory and neuroprotective effects that have been demonstrated in multiple pain models with this first in class therapeutic on Tuesday January 10th at 11:45AM. The Biotech Showcase Investor Conference will be held on January 9-11, 2017 at the Hilton San Francisco Union Square.


Kineta, Inc. is an emerging and sustainable biotech company that fills a void in the biopharmaceutical industry by efficiently advancing therapies from discovery to clinical proof of concept. We actively collaborate with a broad array of private, government and industry partners to advance our innovative research in chronic pain, immuno-oncology and infectious diseases. Kineta has established and is expanding on a diverse pipeline of novel life improving therapies that address critical unmet patient needs. For more information on Kineta, Inc. visit our website, www.Kinetabio.com

KCP-400 is a first in class α9α10 nAChR antagonist with a novel mechanism of action. It is a highly potent synthetic peptide that is derived from the venom of a cone snail. KCP-400 is a non-opioid that has demonstrated robust analgesic, anti-inflammatory and neuroprotective effects across multiple preclinical chronic pain models. It was well tolerated with no observed toxicities in short-term studies.

NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.