Kineta Announces Participation at H.C. Wainwright 23rd Annual Global Investment Conference

Kineta Announces Participation at H.C. Wainwright 23rd Annual Global Investment Conference

Seattle, WA — (August 30, 2021) Kineta, Inc., a clinical stage biotechnology company focused on the development of novel immunotherapies in oncology, announced today that the company will participate in the H.C. Wainwright 23rd Annual Global Investment Conference taking place virtually from September 13-15, 2021.  Shawn Iadonato, PhD, Chief Executive Officer of Kineta will present a corporate overview, that will be viewable online. Members of the management team will also be available for virtual meetings with institutional investors throughout the course of the conference.  For more information on the conference or to register, visit: HCW Events.

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Kineta is a clinical stage biotechnology company with a mission to develop next generation immunotherapies that transform patients’ lives.  We have leveraged our expertise in innate immunity to develop first or best-in-class immunotherapies that address the major challenges with current cancer therapy.  For more information on Kineta visit our website, www.kinetabio.com, and follow us on Twitter, LinkedIn and Facebook.

NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s and Kineta Chronic Pain, LLC’s (KCP) plans for pre-clinical and clinical studies, regulatory filings, investor returns and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s and KCP’s businesses which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and neither Kineta nor KCP undertake any obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.


NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, investor returns and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Contact:
Jacques Bouchy
jbouchy@kineta.us
(206) 378-0400

Kineta Announces Patent Issuance of U.S. Patent for Composition of Matter of KCP506

Kineta Announces Patent Issuance for U.S. Patent Covering Composition of Matter of KCP506, a Novel Non-opioid Therapy for Chronic Pain

Seattle, WA — (August 10, 2021) Kineta Inc, through its subsidiary Kineta Chronic Pain LLC, announced today that the company has received Patent No. 11,014,970 for Modifications and Uses of Conotoxin Peptides from the U.S. Patent and Trademark Office (“USPTO”) related to KCP506, the company’s novel non-opioid therapy in development to treat chronic neuropathic pain. Among other claims, the patent covers the composition of matter of KCP506.

“The allowance of this patent in the U.S. substantially strengthens our intellectual property position, an important milestone for KCP506’s development and potential commercialization,” said Kineta Eric Tarcha, PhD., EVP Research and Development at Kineta. “With a significant need for an effective therapy to treat chronic neuropathic pain, KCP506 has the potential to provide a non-opioid treatment option with a novel drug mechanism relative to conventional pain therapies.”

A Notice of Allowance is issued after the USPTO makes a determination that a patent should be granted from an application. The patent will have a term that expires no earlier than 2035.

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KCP506 may potentially be an effective treatment for many types of chronic neuropathic pain including radiculopathy, chemotherapy-induced peripheral neuropathy, and diabetic neuropathy. The global neuropathic pain market was $6.3 billion in 2019 and is expected to reach to $9.9 billion by 2027.

Kineta, Inc. is a clinical stage biotechnology company committed to developing disruptive life science technologies that address unmet patient needs.  We have leveraged our expertise in immunology to advance a focused pipeline of investigational drugs in oncology and neuroscience.  We actively collaborate with a broad array of private, government and industry partners to advance our innovative products.  For more information on Kineta visit our website, www.kinetabio.com, follow us on Twitter at @kinetabio, LinkedIn and Like us on facebook.com/KinetaBio.


NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s and Kineta Chronic Pain, LLC’s (KCP) plans for pre-clinical and clinical studies, regulatory filings, investor returns and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s and KCP’s businesses which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and neither Kineta nor KCP undertake any obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

 

Contact:
Jacques Bouchy
jbouchy@kineta.us
(206) 378-0400

Kineta Announces Successful Completion of Pre-IND Meeting with the FDA for KVA12.1

Kineta Announces Successful Completion of Pre-IND Meeting with the FDA for KVA12.1

Phase 1/2 clinical studies of the company’s anti-VISTA antibody to commence in mid-2022

Seattle, WA — (July 27, 2021) Kineta, Inc., a clinical stage biotechnology company focused on the development of novel immunotherapies in oncology, announced today that it successfully completed a pre-IND (Investigational New Drug) meeting with the U.S. Food and Drug Administration (FDA) regarding the manufacturing, preclinical and clinical development plan for KVA12.1.  Kineta has gained alignment with FDA on the initial Phase 1/2 clinical trial of the safety and efficacy of Kineta’s KVA12.1 as a single agent and in combination with pembrolizumab in patients with unresectable or metastatic solid tumors.

“We greatly appreciate the FDA’s guidance as we prepare to advance our novel anti-VISTA immunotherapy into the clinic next year”, said Shawn Iadonato, PhD, Chief Executive Officer of Kineta.  “The successful completion of this engagement with the FDA is an important milestone that provides regulatory clarity for KVA12.1 and confidence with the planned development program for this novel anti-cancer immunotherapy.

A pre-IND meeting provides an opportunity for an open communication between a drug development company and the FDA to discuss the IND development plan and to obtain the agency’s guidance for clinical studies of the company’s new drug candidate. The FDA reviewed the IND enabling preclinical data, manufacturing plan and phase 1/2 clinical study protocol synopsis for KVA12.1, provided guidance and addressed Kineta’s questions on the development plan.  Kineta plans to initiate the Phase 1/2 first-in-human clinical studies in mid-2022.

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Kineta, Inc. is a clinical stage biotechnology company committed to developing disruptive life science technologies that address unmet patient needs.  We have leveraged our expertise in immunology to advance a focused pipeline of investigational drugs in oncology and neuroscience.  We actively collaborate with a broad array of private, government and industry partners to advance our innovative products.  For more information on Kineta visit our website, www.kinetabio.com, follow us on Twitter at @kinetabio, LinkedIn and Like us on facebook.com/KinetaBio.


NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, investor returns and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

 

Contact
Jacques Bouchy
jbouchy@kineta.us
(206) 378-0400

Kineta Announces First Participant Dosed in Phase 1 Multiple Ascending Dose Clinical Trial of KCP506

Kineta Announces First Participant Dosed in Phase 1 Multiple Ascending Dose Clinical Trial of KCP506

Seattle, WA — (July 14, 2021) Kineta Inc, through its subsidiary Kineta Chronic Pain LLC, announced today that the first participant has been successfully dosed in a Phase 1 multiple ascending dose (MAD) clinical trial of KCP506, an investigational, first-in-class α9α10 nicotinic acetylcholine receptor (nAChR) antagonist in development for the treatment of chronic neuropathic pain.

The Phase 1, double blinded, placebo controlled, multiple ascending dose study is designed to evaluate the safety, tolerability, and pharmacokinetics of KCP506 in healthy people. The trial is designed to enroll up to 24 participants with safety, tolerability and pharmacokinetic data expected to read out in the second half of 2021.  The company recently completed the single ascending dose (SAD) clinical study on KCP506.

“We are pleased to see KCP506 progress to the Phase 1 MAD clinical study after completing the single ascending dose earlier this year,” said Eric Tarcha PhD, Kineta EVP Research and Development.  “There is such a tremendous unmet need for patients suffering from chronic neuropathic pain conditions.  We are eager to see this novel non-opioid advance through clinical trials and hope it will one day be available for these patients in need.”

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KCP506 may potentially be an effective treatment for many types of chronic neuropathic pain including radiculopathy, chemotherapy-induced peripheral neuropathy, and diabetic neuropathy. α9α10 nAChR antagonists have demonstrated robust analgesic, anti-neuroinflammatory and neuroprotective effects across multiple preclinical chronic pain models.  KCP506 offers the potential for a disease modifying therapy that may slow or halt the progression of chronic pain.  The global neuropathic pain market was $6.3 billion in 2019 and is expected to reach to $9.9 billion by 2027.

Kineta, Inc. is a clinical stage biotechnology company committed to developing disruptive life science technologies that address unmet patient needs.  We have leveraged our expertise in immunology to advance a focused pipeline of investigational drugs in oncology and neuroscience.  We actively collaborate with a broad array of private, government and industry partners to advance our innovative products.  For more information on Kineta visit our website, www.kinetabio.com, follow us on Twitter at @kinetabio, LinkedIn and Like us on facebook.com/KinetaBio.

 


NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s and Kineta Chronic Pain, LLC’s (KCP) plans for pre-clinical and clinical studies, regulatory filings, investor returns and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s and KCP’s businesses which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and neither Kineta nor KCP undertake any obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Contact Jacques Bouchy
jbouchy@kineta.us
(206) 378-0400

Kineta’s Thierry Guillaudeux Participated on Multiple Panel Presentations During Virtual Symposium on VISTA

Kineta’s Thierry Guillaudeux Participated on Multiple Panel Presentations During Virtual Symposium on VISTA: A New Immunotherapy Approach to Treating Cancer

Seattle, WA — (June 24, 2021) Kineta, Inc., a clinical stage biotechnology company focused on the development of novel immunotherapies in oncology, announced today that Thierry Guillaudeux, Ph.D., SVP Immuno-oncology at Kineta, participated on multiple panel presentations during the virtual symposium “VISTA: A New Immune Checkpoint in Cancer, Autoimmunity and Beyond,” that took place on June 18, 2021.

“It was a great pleasure to participate in this symposium focused on VISTA”, said Thierry Guillaudeux of Kineta. “The scientific presentations and discussions from the different panelists clearly emphasized how VISTA is a promising new immuno-oncology target for treating patients with advanced tumors. Its unique mechanism of action involving both an innate and adaptive immune response illustrates that antibody therapy targeting VISTA could be an important new path in cancer treatments with this new generation of checkpoint inhibitors.”

The scientific symposium focused on the emerging checkpoint inhibitor VISTA, its function, the role it plays in several oncology and current development programs. The event was hosted by Randolph Noelle, Ph.D., Professor of Microbiology and Immunology, Department of Microbiology and Immunology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth; and Padmanee Sharma, M.D., Ph.D., Professor, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, University of Texas, MD Anderson Cancer Center.

“Kineta has made tremendous progress developing KVA12.1, our novel anti-VISTA antibody currently in preclinical evaluation”, said Thierry Guillaudeux of Kineta. “We nominated KVA12.1 as our lead clinical candidate earlier this year and have initiated IND enabling studies.  We expect to initiate Phase 1 safety and tolerability studies in mid-2022”.

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Kineta, Inc. is a clinical stage biotechnology company committed to developing disruptive life science technologies that address unmet patient needs.  We have leveraged our expertise in immunology to advance a focused pipeline of investigational drugs in oncology and neuroscience.  We actively collaborate with a broad array of private, government and industry partners to advance our innovative products.  For more information on Kineta visit our website, www.kinetabio.com, follow us on Twitter at @kinetabio, LinkedIn and Like us on facebook.com/KinetaBio.


NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, investor returns and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

 

Contact Jacques Bouchy
jbouchy@kineta.us
(206) 378-0400

Kineta to Participate in “VISTA: A New Immune Checkpoint in Cancer, Autoimmunity and Beyond” Virtual Symposium

Kineta to Participate in “VISTA: A New Immune Checkpoint in Cancer, Autoimmunity and Beyond” Virtual Symposium

Seattle, WA — (June 7, 2021) Kineta, Inc., a clinical stage biotechnology company focused on the development of novel immunotherapies in oncology, announced today that Thierry Guillaudeux, Ph.D., SVP Immuno-oncology at Kineta, will participate in the virtual symposium “VISTA: A New Immune Checkpoint in Cancer, Autoimmunity and Beyond,” taking place on June 18, 2021.

The symposium will focus on the emerging checkpoint molecule VISTA, its function, the role it plays in several disease areas and current development programs. The event will be hosted by Randolph Noelle, Ph.D., Professor of Microbiology and Immunology, Department of Microbiology and Immunology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth; and Padmanee Sharma, M.D., Ph.D., Professor, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, University of Texas, MD Anderson Cancer Center.

Presentation Details:
Dr. Guillaudeux will participate on the following panels during the Symposium:

Session Title:   Discovery of Anti-VISTA Antibodies
Date/Time:      June 18, 2021 from 9:50 AM to 10:35 AM Eastern Time

Session Title:   VISTA Advances into Clinical Development
Date/Time:      June 18, 2021 from 12:20 PM to 1:05 AM Eastern Time

To access the panel discussion please register as an attendee here: https://bit.ly/3hBzIUj

“I am pleased to participate in this exciting event”, said Thierry Guillaudeux of Kineta.  “VISTA is an important target that I believe has a central role in converting cold, hard-to-treat tumors into hot tumors that are more susceptible to treatment.  This myeloid checkpoint has the potential to improve cancer management for patients in a variety of solid tumors,”

Kineta is developing KVA12.1, a novel anti-VISTA antibody in preclinical evaluation for the treatment of solid tumors.  VISTA is a key driver of the immunosuppressive tumor microenvironment (TME) and is overexpressed on myeloid-derived suppressor cells (MDSC) and regulatory T cells (Tregs). It is a critical myeloid cell immune-checkpoint, and VISTA blockade can reprogram suppressive myeloid cells and reactivate antitumor immune function. Blocking VISTA activates an immune cell cascade that increases T cell effector functions to drive an efficient anti-tumor response. Preclinical studies have demonstrated single agent anti-VISTA activity but also demonstrate that targeting VISTA in combination with PD-1, PD-L1 or CTLA-4 can significantly improve the efficacy of those checkpoint inhibitors.

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Kineta, Inc. is a clinical stage biotechnology company committed to developing disruptive life science technologies that address unmet patient needs.  We have leveraged our expertise in immunology to advance a focused pipeline of investigational drugs in oncology and neuroscience.  We actively collaborate with a broad array of private, government and industry partners to advance our innovative products.  For more information on Kineta visit our website, www.kinetabio.com, follow us on Twitter at @kinetabio, LinkedIn and Like us on facebook.com/KinetaBio.


NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, investor returns and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

 

Contact Jacques Bouchy
jbouchy@kineta.us
(206) 378-0400

 

Kineta Closes $10 Million Financing Round to Advance Anti-VISTA Immuno-oncology Program

Kineta Closes $10 Million Financing Round to Advance Anti-VISTA Immuno-oncology Program

Seattle, WA — (June 1, 2021) Kineta, Inc., a clinical stage biotechnology company focused on the development of novel immunotherapies in oncology announced today the close of its $10 million financing round.  Kineta is eligible to receive up to $25 million in additional financing prior to the end of 2021 to further advance the company’s pipeline of novel immunotherapies.  The financing from a syndicate of investors was led by Cheongbo Industrial Co Ltd (CBI).

Proceeds from this financing will advance Kineta’s lead anti VISTA antibody, KVA12.1 to an IND with the US FDA in 2022.

“We are excited to have the confidence of this leading investor syndicate in supporting KVA12.1 and our pipeline of novel immunotherapies.  Closing this financing round further validates the innovative research and development at Kineta”, said Shawn Iadonato, PhD, Chief Executive Officer at Kineta. “These new funds provide the resources to advance the preclinical development of our potential best-in-class anti-VISTA antibody to benefit patients with a broad range of solid tumor cancers.

“The innovative science, company strategy and management team at Kineta are well positioned to develop important new therapeutics for managing cancer”, said Kyungwon Oh, President of CBI.  “We are pleased to join Kineta as a major investor and lead this financing round of the company.”

An investor representative from CBI, to be named later in 2021, will be appointed to the Kineta board of directors.  Shawn Iadonato, Chief Executive Officer and Craig Philips, President at Kineta will be appointed to the CBI board of directors.

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KVA12.1 is Kineta’s lead anti-VISTA antibody in development for the treatment of solid tumors.  VISTA is a key driver of the immunosuppressive tumor microenvironment (TME) and is overexpressed on myeloid-derived suppressor cells (MDSC) and regulatory T cells (Tregs). It is a critical myeloid cell immune-checkpoint, and VISTA blockade can reprogram suppressive myeloid cells and reactivate antitumor immune function. Blocking VISTA activates an immune cell cascade that increases T cell effector functions to drive an efficient anti-tumor response. Preclinical studies have demonstrated single agent anti-VISTA activity but also demonstrate that targeting VISTA in combination with PD-1, PD-L1 or CTLA-4 can significantly improve the efficacy of those checkpoint inhibitors.

Kineta, Inc. is a clinical stage biotechnology company committed to developing disruptive life science technologies that address unmet patient needs.  We have leveraged our expertise in immunology to advance a focused pipeline of investigational drugs in oncology and neuroscience.  We actively collaborate with a broad array of private, government and industry partners to advance our innovative products.  For more information on Kineta visit our website, www.kinetabio.com, follow us on Twitter at @kinetabio, LinkedIn and Like us on facebook.com/KinetaBio.


NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, investor returns and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Contact
Jacques Bouchy
jbouchy@kineta.us
(206) 378-0400

 

 

Kineta Presents New Preclinical Data on its Lead VISTA Antagonist Antibody at the AACR Annual Meeting 2021

Kineta Presents New Preclinical Data on its Lead VISTA Antagonist Antibody at the AACR Annual Meeting 2021

Seattle, WA — (April 12, 2021) Kineta, Inc., a clinical stage biotechnology company focused on the development of novel immunotherapies in oncology, announced today the presentation of new preclinical data on its VISTA antagonist antibody at the American Association for Cancer Research (AACR) Annual Meeting 2021.  Thierry Guillaudeux, PhD, Senior Vice President Immuno-oncology at Kineta, presented a poster detailing new preclinical data on the company’s lead anti-VISTA antibody.

Key results with Kineta’s anti-VISTA lead antibody include the following:

  • Highly specific VISTA binding
  • Activates monocytes and this activation is NK cell dependent
  • Reverses MDSC suppression of T cells
  • Induces strong anti-tumor response as a single agent or in combo-therapies with anti-PD1 in different hard to treat tumor models

“Our lead anti-VISTA antibody has demonstrated exceptional preclinical performance which will enable Kineta to develop a differentiated immunotherapy with a new mechanism of action compared to the current T cell focus immunotherapies” said Shawn Iadonato, PhD, Chief Executive Officer at Kineta. “We are excited to advance IND enabling studies and enter the clinic in early 2022.”

VISTA is a key driver of the immunosuppressive tumor microenvironment (TME) and is overexpressed on myeloid-derived suppressor cells (MDSC) and regulatory T cells (Tregs). It is a critical myeloid cell immune-checkpoint, and VISTA blockade can reprogram suppressive myeloid cells and reactivate antitumor immune function. Blocking VISTA activates an immune cell cascade that increases T cell effector functions to drive an efficient anti-tumor response. Preclinical studies have demonstrated single agent anti-VISTA activity but also demonstrate that targeting VISTA in combination with PD-1, PD-L1 or CTLA-4 can significantly improve the efficacy of those checkpoint inhibitors.

Presentation Details:

Title:                            A fully human anti-vista antibody as a promising therapy against poorly immunogenic tumors
Session Type:              E-Poster Session
Session Title:               Immune Checkpoints
Poster Number:          1637
Presenter:                    Thierry Guillaudeux, PhD

Click on the link below to take you to the Kineta website where you can view the presentation:

VISTA Publications – Kineta VISTA Presentation at AACR

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Kineta, Inc. is a clinical stage biotechnology company committed to developing disruptive life science technologies that address unmet patient needs.  We have leveraged our expertise in immunology and innate immunity to advance a focused pipeline of investigational drugs in oncology and neuroscience.  We actively collaborate with a broad array of private, government and industry partners to advance our innovative products.  For more information on Kineta visit our website, www.kinetabio.com, follow us on Twitter at @kinetabio, LinkedIn and Like us on facebook.com/KinetaBio.

NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s and its affiliates’ plans for pre-clinical and clinical studies, regulatory filings, investor returns and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s and its subsidiaries’ businesses which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and neither Kineta nor its affiliates undertake any obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Contact
Jacques Bouchy
jbouchy@kineta.us
(206) 378-0400

 

Kineta Presents Clinical Study Results of LHF-535 at the International Conference on Antiviral Research (ICAR)

Kineta Presents Clinical Study Results of LHF-535 at the International Conference on Antiviral Research (ICAR)

Safety, tolerability and pharmacokinetic profile established in Phase 1 clinical study

Seattle, WA — (March 25, 2020) Kineta, Inc., a clinical stage biotechnology company focused on the development of novel immunotherapies, announced today the presentation of new clinical data on LHF-535 at the International Conference on Antiviral Research (ICAR) Virtual Conference 2021.  Sean Amberg, PhD, Director of Biodefense Initiatives at Kineta, presented the clinical data establishing the safety, tolerability, and pharmacokinetic profile of LHF-535. 

LHF-535 is a first-in-class small molecule antiviral in development as a therapeutic to treat Lassa fever and other viral hemorrhagic fevers of arenavirus origin.  The human safety and pharmacokinetics of LHF-535 was evaluated in a Phase 1b trial in healthy volunteers, using a 14-day oral dosing regimen. A total of 24 healthy participants were enrolled in the clinical study.  

Key findings from the poster presentation include the following:

  • LHF-535 is well tolerated
  • No concerning adverse events or safety issues
  • Pharmacokinetics are consistent with antiviral efficacy in preclinical models of Lassa fever
  • Clinical results support evaluation in a Lassa fever infected patient population 

“As we have learned from the COVID pandemic, emerging viral outbreaks can have a tremendous impact on individuals, families and communities across the globe” said Eric Tarcha, PhD, EVP Research and Development at Kineta. “We are encouraged by these positive clinical study results for LHF-535 as there are no therapeutic options for patients infected with Lassa fever.  The unmet need is tremendous both for patients in West Africa where Lassa fever is endemic as well as potentially throughout the world.”

Presentation Details:

Poster Title:         Clinical Evaluation of Lassa Fever Antiviral LHF-535 in a 14-day Repeat Dose Study in Healthy Volunteers

Date/Time:          March 24, 2021 from 11:00 AM to 12:00 PM Eastern Time

Presenter:              Sean Amberg, PhD

Click on the link below to take you to the Kineta website where you can view the presentation:
LHF-535 Publications – Kineta LHF-535 Poster Presentation at ICAR Virtual Conference 2021 

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LHF-535 is a first-in-class antiviral treatment with potent activity against Lassa and other arenaviruses. It inhibits virus entry into target host cells and serves to suppress viral replication. It has demonstrated safety and efficacy in multiple preclinical models. LHF-535 is a once daily oral therapeutic.  Safety, tolerability and pharmacokinetics have been established in Phase 1 clinical studies in healthy volunteers.  Kineta is receiving funding from the Wellcome Trust and the National Institutes of Health to advance the clinical development of LHF-535 in patients with Lassa fever and to evaluate its activity against other arenaviruses.  

Kineta, Inc. is a clinical stage biotechnology company committed to developing disruptive life science technologies that address unmet patient needs.  We have leveraged our expertise in immunology and innate immunity to advance a focused pipeline of investigational drugs in oncology and neuroscience.  We actively collaborate with a broad array of private, government and industry partners to advance our innovative products.  For more information on Kineta visit our website, www.kinetabio.com, follow us on Twitter at @kinetabio, LinkedIn and Like us on facebook.com/KinetaBio. 

NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s and its affiliates’ plans for pre-clinical and clinical studies, regulatory filings, investor returns and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s and its subsidiaries’ businesses which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and neither Kineta nor its affiliates undertake any obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Contact Jacques Bouchy
jbouchy@kineta.us
(206) 378-0400