January 22, 2018 in Kineta Press Release

Kineta Immuno-oncology Announces Presentation on Novel RIG-I Agonists at Immuno-Oncology Frontiers World Conference

Kineta Immuno-oncology Announces Presentation on Novel RIG-I Agonists at Immuno-Oncology Frontiers World Conference

SEATTLE, WA, January 22, 2018 – Kineta Immuno-oncology, LLC, a biotechnology company focused on developing disruptive technologies to turn cold tumors hot, today announced that they have been invited to present at the Immuno-Oncology Frontiers World Conference sponsored by Phacilitate. Dr. Kristin Bedard, Kineta Immuno-oncology Chief Scientific Officer, will present at 2:50PM EST on January 24, 2018. The conference takes place on January 22-25 at the Hyatt Regency Hotel in Miami, FL.

Dr. Bedard will present on the proof of concept compound, KIN131A, which activates RIG-I-dependent signaling to stimulate chemokine/cytokine production by human PBMCs, and induces direct activation of dendritic cells. In colon carcinoma cells, KIN131A treatment induces the intrinsic apoptosis pathway and triggers immunogenic cell death (ICD) in a RIG-I dependent manner. Additionally, in vivo experiments demonstrated tumor immunity as KIN131A inhibits tumor growth, enhances survival and causes complete regression of tumor growth in approximately 30% of mice. Mice showing complete tumor regression were resistant to re-challenge up to 6 months after primary tumor implantation. Animals that were responsive to KIN131A treatment also demonstrated an increase in tumor antigen specific T cells compared to tumor bearing animals.

“These data demonstrate that the RIG-I agonists activate the innate immune response, induce ICD in tumor cells in vivo and elicit an anti-tumor memory T cell response controlling tumor growth”, said Dr. Bedard. “The induction of ICD by small molecule RIG-I agonists may provide a unique immunotherapeutic opportunity to induce or boost the antitumor immune response in patients and enhance the efficacy of checkpoint inhibitor-mediated immunotherapy.”

Kineta, Inc. is an emerging biotech company that fills a void in the biopharmaceutical industry by efficiently advancing first in class immuno-therapies from discovery to proof of concept.  Kineta is developing a focused pipeline of novel therapies that address critical unmet patient needs in oncology, chronic pain and biodefense. We actively collaborate with a broad array of private, government, biodefense and industry partners to advance our innovative research. For more information on Kineta, Inc. visit our website, www.kinetabio.com

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